Parkinson's Disease Resource Center
Treatment
Association Between Intraoperative Local Field Potentials, Lead Location, and Motor Outcomes in Patients Undergoing Deep Brain Stimulation of the Subthalamic Nucleus for Parkinson’s Disease
Neurosurgery
This article demonstrates how precise electrode placement in Deep Brain Stimulation (DBS) significantly influences clinical outcomes in Parkinson’s disease. It highlights the value of using Local Field Potential (LFP) biomarkers and imaging data to optimize therapeutic targeting, potentially improving patient outcomes and guiding more personalized DBS programming strategies.
Read MoreExercise Strategies for Parkinson Disease Management
Strength and Conditioning Journal
This article emphasizes the therapeutic role of exercise in managing both motor and nonmotor symptoms of Parkinson’s disease. It provides practical, personalized exercise guidelines tailored to disease progression, helping clinicians and exercise professionals better support patients in integrating physical activity into daily life. Understanding the barriers and motivators to exercise can also enhance patient adherence and improve long-term functional outcomes.
Read MoreMicroglial response to aging and neuroinflammation in the development of neurodegenerative diseases
Neural Regeneration Research
This article explores the role of microglia in neurodegenerative diseases, emphasizing their response to aging and chronic inflammation. The review highlights how different states of microglial activation can influence the development of diseases like Alzheimer's, Huntington's, and Parkinson's. Understanding these mechanisms can aid in developing treatments that shift microglia from a neurotoxic to a neuroprotective state. This knowledge could lead to new therapeutic strategies for managing neurodegenerative diseases, improving patient outcomes.
Read MoreParkinson’s disease – current treatment
Current Opinion in Neurology
This article reviews recent advancements in the treatment of both motor and non-motor symptoms of Parkinson's disease (PD). It highlights new formulations of levodopa that optimize motor fluctuations and on-demand apomorphine for treating motor off-periods. The article also discusses promising new agents for non-motor symptoms like constipation and sleep disorders, as well as the potential benefits of expiratory muscle strength training for oropharyngeal dysphagia. Additionally, it emphasizes the importance of being familiar with a broad range of treatment options to manage the diverse symptoms of PD effectively.
Read MorePredicting Sleep Quality Improvement in Parkinson’s Disease Patients Post-DBS: A Nomogram Approach
Neurosurgery
This article investigates the factors influencing sleep disorder improvement in Parkinson's disease (PD) patients after deep brain stimulation (DBS) of the subthalamic nucleus (STN). The study identifies key predictors such as preoperative medication responsiveness, MMSE scores, and HAMA scores, which can help tailor treatment plans. Additionally, the development of a nomogram model with strong predictive accuracy offers a valuable tool for forecasting sleep quality improvements post-surgery. These insights can enhance patient care and optimize treatment strategies for PD-related sleep disorders.
Read MoreRosa moschata ameliorates haloperidol-induced Parkinson’s disease via reduction of neurodegeneration and oxidative stress
Asian Pacific Journal of Tropical Biomedicine
This article investigates the potential neuroprotective effects of Rosa moschata extract on haloperidol-induced Parkinson's disease (PD) in rats. The study shows significant improvements in motor functions and muscle strength, along with increased levels of beneficial neurotransmitters and antioxidants. Additionally, the extract reduced oxidative stress and neurodegeneration markers, suggesting its potential for PD management. These findings provide a basis for further research into the efficacy and molecular mechanisms of Rosa moschata extract, which could lead to new treatment options for PD patients.
Read MoreVelocity-Based Training Affects Function, Strength, and Power in Persons with Parkinson’s Disease
Journal of Strength and Conditioning Research
This article explores the effects of velocity-based training (VBT) on functional performance, strength, and power in Parkinson's disease (PD) patients. The study demonstrates significant improvements in various physical performance metrics, such as gait speed, sit-to-stand time, and muscle strength, after 12 weeks of supervised VBT. These findings suggest that VBT can be an effective training modality for enhancing physical function in PD patients. Additionally, the study provides insights into the specific protocols and outcomes, helping healthcare providers design better exercise programs for PD management.
Read MoreLong-term Outcomes (15 Years) After Subthalamic Nucleus Deep Brain Stimulation in Patients With Parkinson Disease
Neurology
This article demonstrates the long-term efficacy of deep brain stimulation of the subthalamic nucleus (STN-DBS) in treating motor complications in Parkinson's disease (PD) patients. The study shows significant reductions in dyskinesia and "off" time, as well as a substantial decrease in dopaminergic drug usage, even 15 years after surgery. Additionally, it highlights improvements in quality of life (QoL) and manageable device-related adverse events. These findings provide valuable insights into the sustained benefits of STN-DBS, helping healthcare providers optimize long-term treatment strategies for PD patients.
Read MoreTherapeutic potential of Glycyrrhiza glabra L. in managing oxidative stress-induced disorders
Journal of Drug Research in Ayurvedic Sciences
This article reviews the therapeutic potential of Glycyrrhiza glabra (licorice) in managing oxidative stress-related conditions. The review highlights key bioactive molecules like glycyrrhizin and isoliquiritin, which modulate antioxidant enzyme activities and inhibit free radical production. These findings suggest that licorice could be beneficial in treating diseases such as cancer, neurodegenerative disorders, and inflammatory conditions. Additionally, the article identifies gaps in current knowledge and calls for further research to fully exploit the medicinal benefits of G. glabra, offering valuable insights for future therapeutic applications.
Read MoreA Systematic Review and Meta-analysis of the Effect of Apomorphine in Patients with Parkinson’s Disease
Journal of Advanced Trends in Medical Research
This article is important because it offers a comprehensive analysis of the efficacy of apomorphine in treating Parkinson's disease (PD). The systematic review and meta-analysis provide robust evidence on the effectiveness of apomorphine in improving motor symptoms and reducing OFF time in PD patients. Additionally, the study highlights the safety profile of apomorphine, which is crucial for making informed treatment decisions. Understanding these findings can help healthcare providers optimize treatment strategies and improve patient outcomes in PD management.
Read MoreNationwide Retrospective Analysis of Combinations of Advanced Therapies in Patients With Parkinson Disease
Neurology
This article is important because it offers valuable insights into the efficacy of changing or combining advanced therapies (ATs) for Parkinson's disease (PD) patients. The study, based on data from 22 PD centers in Germany, shows significant improvements in clinical outcomes and reduced side effects with AT modifications. It highlights the importance of tailoring ATs to individual patient needs, depending on dominant symptoms and adverse effects. Additionally, the findings suggest that combining ATs can be as beneficial as introducing the first AT, providing a strong basis for optimizing treatment strategies.
Read MoreResearch
Parkinson Disease and the Gut: A Primer for Gastroenterologists
The American Journal of Gastroenterology
This article highlights the emerging role of the gut-brain axis in the pathogenesis and progression of Parkinson’s disease. It suggests that gastrointestinal symptoms may precede motor signs by decades, offering potential for earlier diagnosis and risk stratification. Understanding the gut’s influence on neuroinflammation and treatment response could open new avenues for disease-modifying therapies and more personalized care strategies.
Read MoreParkinson’s disease – genetic cause
Current Opinion in Neurology
This article offers a comprehensive overview of the genetic factors underlying Parkinson's disease (PD). It highlights key mutations in both autosomal dominant and recessive genes that contribute to PD, providing insights into the genetic complexity of the disease. The article also introduces new putative disease-causing genes, which could influence future diagnostic and therapeutic strategies. Understanding these genetic aspects can help healthcare providers predict and manage PD more effectively, paving the way for precision medicine in treating this condition.
Read MoreRoles of neuronal lysosomes in the etiology of Parkinson’s disease
Neural Regeneration Research
This article delves into the molecular etiology of Parkinson's disease (PD), focusing on the role of the autophagy-lysosome system. The review highlights how genetic and genomic advancements have identified key proteins and cellular processes involved in PD, particularly those related to lysosome function. Understanding these mechanisms can aid in developing targeted therapies that modify disease progression. Additionally, the article discusses the potential risks of indiscriminately enhancing autophagy, emphasizing the need for precise adjustments in lysosome functionalities to improve neuronal and glial cell functions.
Read MoreImaging-Guided Subthalamic Nucleus Deep Brain Stimulation Programming for Parkinson Disease
Neurology
This article compares two programming methods for deep brain stimulation (DBS) in Parkinson's disease (PD) patients, highlighting their efficacy and patient burden. The study shows that both conventional ring-mode programming (CP-RM) and image-guided volume of tissue activated (IG-VTA) programming provide similar improvements in motor function. However, IG-VTA programming is associated with shorter hospital stays and fewer hospitalizations, reducing the burden on patients and clinicians. These findings can help healthcare providers optimize DBS programming methods to enhance patient outcomes and streamline care.
Read MoreOFF-Time
Subcutaneous infusions treat “off” periods in Parkinson disease
AJN, American Journal of Nursing
Onapgo offers movement disorder specialists and neurologists a valuable option for managing “off” episodes in advanced Parkinson’s disease through continuous subcutaneous infusion of apomorphine. It provides nearly two hours less “off” time compared to placebo, helping to stabilize motor and nonmotor symptoms when oral medications fall short. Its non-opioid profile, established efficacy, and flexible titration approach make it a practical and effective addition to personalized Parkinson’s care.
Read MoreOff-time Treatment Options for Parkinson’s Disease
Neurology and Therapy
This article offers a comprehensive overview of treatment options for managing motor fluctuations (MF) in Parkinson's disease (PD). It discusses both pharmacological and advanced therapies, including new once-a-daily compounds and on-demand rescue therapies, providing insights into their efficacy and application. The article also addresses complex therapies like deep brain stimulation and device-aided treatments, highlighting their potential benefits when oral/on-demand options are insufficient. Additionally, it emphasizes the importance of personalized treatment decisions based on patient preferences, symptoms, and socio-economic factors, which is crucial for optimizing patient care.
Read MoreThe Efficacy of Istradefylline for Treating Mild Wearing-Off in Parkinson Disease
Clinical Neuropharmacology
This article examines the efficacy of istradefylline, an adenosine A2A antagonist, in treating mild wearing-off symptoms in Parkinson's disease (PD) patients. The study found that 20 mg/day of istradefylline significantly improved motor functions over 12 weeks, as evidenced by reductions in ON-UPDRS-III scores. The results suggest that istradefylline can be effective for PD patients with shorter daily OFF times, providing valuable insights for healthcare providers on optimizing treatment strategies. Additionally, the article highlights the dose-dependent effects of A2A antagonists in relation to L-DOPA, which is crucial for tailoring treatment regimens.
Read More
© 2025 Wolters Kluwer. All right reserved.